The Differences Between Injectable and Infusion Biologics for AxSpA

Axial spondyloarthritis (axSpA) is a type of inflammatory arthritis that mainly affects the spine and pelvic joints. Biologics – medicines made from living organisms – can be a powerful treatment option for axSpA. They help reduce inflammation, slow disease progression, and improve symptoms. Typically, biologics are given in 2 ways: subcutaneous (under the skin) injections or intravenous (IV) infusions.^1,2

Injectable biologics

Injectable biologics are injections. These medicines come in pre-filled syringes or pens. You can give yourself the injection at home, usually in your stomach, upper arm, or thigh.^2-4

Pros of injectable biologics

The pros of injectable biologics include:³

• Convenience – Injectables can be given at home. There is no need to visit a doctor’s office or clinic to get your injections.
• Time-saving – Injections only take a few minutes.
• Flexibility and control – You can choose the time and place for your injections.

Cons of injectable biologics

The cons of injectable biologics include:^3,4

• Self-injection – Some people may feel uncomfortable or anxious about giving themselves injections.
• Frequent dosing – Depending on the specific medicine, injections may be required once a week or every 2 weeks.
• Storage – Many injectables need to be stored in the refrigerator.

Infusion biologics

Infusion biologics must be given by a healthcare professional. They will insert an IV into your arm to deliver the medicine. These IV infusions usually take place in a doctor’s office, clinic, or hospital.^2,3

Pros of infusion biologics

The pros of infusion biologics include:³

• Less frequent dosing – Infusions are usually needed less often than injections. This means fewer treatments compared to injectables.
• No self-injection – Since a healthcare professional gives you the medicine, you do not need to worry about giving yourself injections.
• Professional monitoring – During the infusion, a healthcare provider can monitor you for any side effects.

Cons of infusion biologics

The cons of infusion biologics include:³

• Time commitment – Infusion appointments can take several hours, and you need to visit a clinic each time.
• Scheduling – You have to work around the clinic’s availability, which may limit your flexibility.
• Cost – Infusions are generally more expensive because they require a healthcare professional and clinic resources.

The cost of biologics

Biologics, whether injectables or infusions, can be expensive. The cost of biologics can vary based on the medicine and your insurance coverage.^3,5

Infusions tend to cost more due to the clinic visits and professional administration required. However, insurance may cover a big portion of the cost for both options. Some drug (pharmaceutical) companies also offer patient assistance programs to help with the costs.^3,5

Talk with your insurance provider to understand your out-of-pocket expenses. Some people may find that the overall cost of an infusion is higher, but they only need to visit the clinic every few weeks. On the other hand, the cost of injectables may seem lower, but more frequent dosing can add up over time.^3,5

What do people with axSpA prefer?

Whether you choose injectable or infusion biologics comes down to:^3-5

• The severity of your disease and your doctor’s recommendation
• Your financial means
• Convenience
• Personal preference

Many people like the convenience and control of injectables, especially if they have busy schedules. Others find comfort in receiving care in a clinic setting, where they can ask questions and be closely monitored.³

For people who are uncomfortable with needles, the thought of self-injecting can be scary. But some people prefer to avoid the time commitment required for infusions. Ultimately, the choice comes down to what fits your lifestyle, comfort level, and treatment needs.³

Talk with your doctor

Discuss your options with your doctor. They can help you make an informed decision that works best for your health and lifestyle. Both injectable and infusion biologics offer effective relief from axSpA symptoms, so it is about finding which one you respond to best.¹